Despite their importance and usefulness, microtomes can encounter a range of common problems that can affect their performance and the quality of the slices they produce.

One of the most common issues is blade chatter, which can result in uneven or jagged slices. This can be caused by a misaligned blade or insufficient lubrication. Another common problem is the presence of artifacts or debris on the slices, which can be caused by improper cleaning or preparation of the specimen.

Microtomes may experience mechanical issues such as slipping or vibration, which can affect the precision and accuracy of the cutting process. To troubleshoot these problems, it is important to carefully examine the microtome and identify the source of the issue.

Solutions may include adjusting the blade, cleaning or preparing the specimen differently, or repairing or replacing faulty components. Regular maintenance and calibration of microtomes can also help prevent common problems and ensure that they continue to produce high-quality, accurate slices of biological specimens.