Treatment typically involves a combination of medications, counseling, and behavioral therapy. In addition to the risks associated with codeine itself, combining codeine with other medications or substances can increase the risk of adverse effects. For example, combining Codeine with alcohol or benzodiazepines can increase the risk of respiratory depression and overdose. Medications such as buprenorphine and methadone can help alleviate withdrawal symptoms and reduce cravings.

Behavioral therapies, such as cognitive-behavioral therapy (CBT) and contingency management, can help individuals learn coping skills and develop healthier behaviors. In severe cases, inpatient treatment may be necessary. Inpatient treatment provides individuals with around-the-clock care and support, as well as access to a range of therapeutic services. Preventing codeine addiction begins with responsible prescribing practices. Healthcare providers should carefully evaluate a patient's medical history and the potential risks and benefits of prescribing codeine before writing a prescription. Additionally, healthcare providers should closely monitor patients who are taking codeine and adjust their dosage as necessary.

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