Aprepitant API is an active pharmaceutical ingredient (API) used in the manufacture of Aprepitant, a prescription medication for the prevention of chemotherapy-induced nausea and vomiting (CINV). Aprepitant is a type of drug called a neurokinin-1 (NK-1) antagonist. NK-1 is a receptor that is found in the central nervous system and is involved in the vomiting process. Aprepitant works by blocking the binding of NK-1 to its ligand, which helps to prevent nausea and vomiting.

Aprepitant API is a white to off-white powder that is insoluble in water. It is typically manufactured using a multi-step chemical synthesis process. Once the API is manufactured, it is formulated into finished dosage forms such as capsules or tablets.

Aprepitant API is a potent drug substance, and its manufacture and use is subject to strict regulatory requirements. In the United States, Aprepitant API is manufactured by Merck & Co., Inc.

Here are some additional details about Aprepitant API:

· CAS number: 113665-50-7

· Molecular formula: C23H27ClF3N5O

· Molecular weight: 470.96 g/mol

· Melting point: 144-146 °C

· Solubility: Insoluble in water, soluble in organic solvents such as ethanol and acetone

Aprepitant API is a complex molecule, and its synthesis requires specialized equipment and expertise. It is important to note that Aprepitant API is a prescription drug, and it should only be used under the supervision of a qualified healthcare professional.

Aprepitant API is a valuable tool in the prevention of CINV, a common and debilitating side effect of chemotherapy. Aprepitant has been shown to be effective in reducing the incidence and severity of both acute and delayed CINV. This can help to improve the quality of life for patients undergoing chemotherapy treatment.