D-(+)-Trehalose, isolated from Saccharomyces cerevisiae, can be used as a food ingredient and pharmaceutical excipient.
Storage Conditions：
Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
Trehalose should be stored in a cool, dry place in a well-sealed container.
Uses
Trehalose, also known as mycose or trehalose, is a natural alpha-linked disaccharide formed by an α,α-1,1-glucoside bond between two α-glucose units. In 1832, H.A.L. Wiggers discovered trehalose in an ergot of rye, and in 1859 Marcellin Berthelot isolated it from trehala manna, a substance made by weevils, and named it trehalose. It can be synthesized by bacteria, fungi, plants, and invertebrate animals. It is implicated in anhydrobiosis — the ability of plants and animals to withstand prolonged periods of desiccation. It has high water retention capabilities and is used in food and cosmetics. The sugar is thought to form a gel phase as cells dehydrate, which prevents disruption of internal cell organelles, by effectively splinting them in position. Rehydration then allows normal cellular activity to be resumed without the major, lethal damage that would normally follow a dehydration/rehydration cycle. Trehalose is not an antioxidant, because it is a non-reducing sugar and does not contain nucleophilic groups in its molecule. However, it was reported to have antioxidant effects. Extracting trehalose was once a difficult and costly process, but circa the year 2000, the Hayashibara company (Okayama, Japan) confirmed an inexpensive extraction technology from starch for mass production. Trehalose is used in a broad spectrum of applications.
Trehalose is an important pharmaceutical raw material, and pharmaceutical companies need to find reliable channels to purchase it in large quantities. So, where can a large number of purchases be made to meet the needs of pharmaceuticals?
Firstly, the chemical raw material market is a major procurement location. In many large cities, there are specialized chemical raw material markets that supply various chemical raw materials, including trehalose. These markets typically gather multiple suppliers, providing diverse choices and competitive prices. Pharmaceutical companies can obtain a large amount of trehalose through direct negotiations with suppliers in the market.
Secondly, the pharmaceutical raw material trading platform is also an important procurement channel. With the development of the Internet, many online platforms specialize in providing trading services for chemical raw materials. Pharmaceutical companies can search and contact suppliers on these platforms for large-scale procurement. This approach can save time and cost, and provide a wider range of options.
In addition, direct cooperation with suppliers in trehalose production areas is also a common method of bulk procurement. Trehalose mainly comes from the extraction and processing of seaweed, so some coastal areas or developed fishing areas may have more trehalose suppliers. Establishing cooperative relationships with these suppliers can ensure that a large amount of trehalose is obtained directly from the production source and may result in more competitive prices.
Finally, pharmaceutical companies can also consider collaborating with trehalose distributors or agents. These distributors typically collaborate with multiple suppliers and have a wide supply network. By collaborating with distributors, pharmaceutical companies can obtain more flexible procurement methods and comprehensive services to meet the demand for large-scale procurement.
In summary, pharmaceutical companies can purchase a large amount of trehalose through various methods such as chemical raw material markets, pharmaceutical raw material trading platforms, cooperation with suppliers in production areas, or cooperation with distributors. Choosing appropriate procurement channels can ensure the stability of supply and the reliability of quality, meeting the needs of pharmaceuticals.