Imatinib has a selective inhibitory effect on the Bcr-Abl tyrosine kinase enzyme, formed by the fusion of the Bcr gene and the Abl proto-oncogene (Abelson), at the cellular level, selectively suppresses proliferation and causes apoptosis of cell lines expressing Bcr-Abl tyrosine kinase, including immature leukemia cells produced in patients with Philadelphia chromosome-positive chronic myeloid leukemia and acute lymphoblastic leukemia.
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